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3.5 HSP transcription, translation, and the molecular chaperone activation phase As the transcription and translation of HSP genes are activated under the guidance of HSF1, the cell enters the molecular chaperone activity phase (Figure 2c) (Rosenzweig et al., 2019)
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It is worth noting that fatigue may appear before anaemia develops in some cases, as the neurological and metabolic effects of B12 deficiency can manifest independently of haematological changes
As mentioned above, it is not definitive that this is indeed a problem for people with IBS and more research is needed to understand this better
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